A Fickian diffusion transport process with features of transport catalysis. Doxorubicin transport in human red blood cells.
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A Fickian diffusion transport process with features of transport catalysis. Doxorubicin transport in human red blood cells
The transport of the antineoplastic drug doxorubicin (Adriamycin) in human red blood cells was investigated by measuring the net efflux from loaded cells. Previous data indicated that doxorubicin transport was a Fickian diffusion transport process of the electrically neutral molecule through the lipid domain of the cell membrane (Dalmark, 1981 [In press]). However, doxorubicin transport showed ...
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Dear Sir: In our work (1) we have made use o f Stein and Lieb's (2) approach to obtain values of ratios o f molecular rate constants related to t ranspor t steps. In o rd e r to rationalize ou r results we assumed at the t ime that in equi l ibr ium-exchange conditions the concent ra t ion o f the carrier-substrate complex was h igher at the external surface of the cell and that the tu rnover r...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1981
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.78.4.349